Abstract
SummaryMale Swiss-Webster mice were injected ip with 400 mg/kg of the antioxidant buty-lated hydroxytoluene (BHT). Between 2 and 5 days after BHT, there was a marked increase in the incorporation of thymidine into pulmonary DNA; 7 and 9 days after BHT, incorporation of thymidine fell towards values found in control animals. The increased incorporation of thymidine was accompanied by a net and significant increase in total lung weight and a persistent elevation of total lung DNA. Butylated hydroxytoluene did not stimulate DNA synthesis in liver, kidney, spleen, or gastrointestinal tract. Butylated hydroxytoluene could be used as a tool to study the biochemical events leading to or accompanying stimulated DNA synthesis and cell growth in lung.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
