Abstract
The effects of fatty acids on adenosine 3',5'-monophosphate (cAMP) accumulation in rat anterior pituitary gland were studied in vitro. Of all the fatty acids tested, namely oleic, lifiolenic, γ-linolenic, cis-5-eicosaenoic, cis-8, 11, 14-eicosatrienoic, cis-11, 14, 17-eicosatrienoic, arachidonic, and cis-5, 8, 11, 14, 17-pentaenoic, only the direct precursors of prostaglandin e 1 ( cis-8, 11, 14-eicosatrienoic acid) and prostaglandin E 2 (arachidonic acid) increased intracellular cAMP levels. Stimulation was apparent within l min of incubation and reached a maximum at 15 min. At longer time intervals, the concentration of cAMP decreased to basal level. Calcium is not essential for the action of fatty acids while theophylline does not result in any qualitative change. It is concluded that fatty acids stimulate adenylate cyclase activity in rat anterior pituitary tissue and that prostaglandin synthesis is probably involved as mediator of their action.
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