Abstract
The present work reports the modulatory role of oxytocin on cortisol secretion by the interrenal cells in Clarias batrachus. Administration of dexamethasone @ 2.5 mg kg-1 body weight and captopril @8.3 mg kg-1 body weight for seven consecutive days resulted in a sharp fall in the cortisol level from 23.82 ± 1.248 µg dl-1 to 8.9 ± 3.47 µg dl-1. Treatment with oxytocin along with the above modulators resulted in an increase in cortisol level from 8.9 ± 3.47 µg dl to 12.84 ± 0.311 µg dl. Administration of oxytocin only, in the intact fish showed a stimulatory effect on the cortical production resulting in an increase from 23.82 ± 1.248 µg dl-1 to 31.9 ± 1.173 dl-1. The data were subjected to paired sample t-test and found to be significant at 95% confidence level. The present investigation clearly indicates a stimulatory effect of oxytocin in the regulation of cortisol secretion. Key words: Cortisol, oxytocin, Clarias batrachus
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