Abstract
The induction of CL in bovine polymorphonuclear granulocytes (PMN) by bovine herpes virus Type I was studied. Virus and virus-infected bovine embryonic lung cells were unable to stimulate cellular light emission. When virus and infected cells were incubated in the presence of immune serum, a burst of CL was induced in PMN. The mechanism of CL induction was dependent on the antibody Fc portion, as F(ab') 2 fragments bound to antigen were unable to stimulate CL. These observations suggest that PMN may exert antiviral activity in the presence of a specific antibody. In addition, the measurement of antibody-induced CL represents a highly sensitive tool for the study of antigens present on the surface of viruses, and of viral antigens expressed on cell surfaces.
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