Abstract
The ingestion of carbon and benzpyrene particles in vitro by rat peritoneal macrophages, baby hamster kidney fibroblasts (BHK-21) and mouse L-cells has been shown to be significantly stimulated by the inclusion of histone or polylysine in the culture medium. Parallel studies using methylated bovine albumin did not significantly stimulate carbon or benzpyrene uptake relative to untreated control cultures. Incubation of carbon particles with histone before inclusion in the culture medium of macrophages resulted in the same degree of uptake as in the cultures where carbon and histone were added independently of each other. The implications of these findings to in vivo chemical carcinogenesis are examined.
Highlights
BASIC proteins and poly-amino-acids that a variety of basic proteins are have been shown to be taken up by released from tissue and blood cells mammalian cells at rates up to 3000 damaged in the course of infection and times greater than serum albumin and, inflammation
The results of these studies indicate that some basic peptides, such as histone or polylysine, can enhance the ingestion of certain particles by macrophages and fibroblasts in vitro
The results indicate that carbon particles and histone interact when stirred together in saline and, when resuspended in media containing macrophages, the carbon is phagocytosed more rapidly than untreated material
Summary
These observations illustrate tions with respect to both in vivo and in the cell-surface activities of certain basic vitro chemical carcinogenesis we studied poly-amino-acids and show their capacity the effect of histone and other basic for inducing increased ingestion of other polypeptides on the uptake of carbon and materials into cells. It has been benzpyrene by macrophages and fibrodemonstrated that protamine and other blasts in vitro.
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