Abstract
CATABOLITE repression is known to involve the inhibition of enzyme induction by glucose and/or glucose metabolites such as glucose-6-phosphate and gluconate-6-phosphate1. Enzymes known to be sensitive to catabolite repression include those of the lactose Operon, L-arabinose operon, as well as the histidase and tryptophanase enzymes2–4. An important step in the elucidation of the nature of the glucose effect in catabolite repression was the discovery that 3′,5′-cyclic adenosine monophosphate (cAMP) is able to relieve catabolite repression5. It is now known that glucose and/or glucose metabolites lower the endogenous levels of cAMP. In glucose-grown cultures of Escherichia coli, irrespective of the glucose concentration used, cAMP synthesis only starts after complete depletion of glucose in the culture medium6.
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