Abstract
The steroidogenic activities of NIH ovine FSH and LH have been studied in vitro in dissected circumtesticular Leydig cells and a seminiferous tubule/interstitium preparation from the testis of the lizard Cnemidophorus tigris. Results are compared with the 3β-HSD histochemical properties of the tissues investigated. Both types of tissue produced androgens and responded to the two gonadotropins. Basal levels and maximal stimulated levels of androgen production by the circumtesticular Leydig cells were 10-fold greater than in the remainder of the testes. NIH-FSH and LH were equipotent on the Leydig cells but LH was about five times more potent on the tubule/interstitium tissues. Thus, the Leydig cells appear to be the major source of androgen and the site of action for both gonadotropins in the lizard testis
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