Abstract
Adenylate cyclase activity in the lymph node particles from rats undergoing graft-versus-host reaction was found to increase markedly. Such a change in the enzyme activity does not appear to be due to a shift in pH optima. Sodium fluoride failed to stimulate the adenylate cyclase activity in preparations from animals with graft-versus-host disease. These results suggest that the cellular immune process is associated with alteration in the adenylate cyclase activity.
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