Abstract
To investigate the possible function(s) of T cell receptor (TcR) γδ expressing lymphocytes, we generated a series of γδ TcR surface positive hybridomas. Spontaneous producers of IL-2 were quite common among these hybridomas, particularly those expressing a certain Vδ gene or gene family (VδM23). Several other experiments indicated that IL-2 production in these hybridomas is triggered via TcR γδ. Surprisingly, every spontaneously reactive γδ+ hybridoma was further stimulated by purified protein derivative (PPD) of Mycobacterium tuberculosis, perhaps due to crossreaction with a bacterial antigen homologous to certain eukaryotic heat shock proteins. The finding of an antigen recognized by a γδ TcR could aid in understanding the functional role of the γδ TcR+ lymphocytes.
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