Abstract
DESPITE the large volume and sodium concentration of digestive secretions, the losses of sodium incurred with faeces are negligible in normal circumstances1,2. Return to the organism of sodium present in the intestinal lumen depends in all likelihood on active transport process(es); in the case of the toad colon, this had been established by Ussing and Andersen3, who showed that sodium moves from the mucosal to the serosal surface in the absence of electrochemical potential gradient; furthermore, this movement was expressed quantitatively by the current required to annihilate the electrical potential difference which can be recorded across the membrane.
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