Stimulating Effects of Cisapride on Antroduodenal Motility in the Conscious Dog

Abstract

The effects of cisapride on gastroduodenal motility and gastric emptying were studied in conscious dogs, implanted with strain gauge force transducers or gastric cannulas. In the digestive state, cisapride (1.25 mg/kg p.o.) doubled contractile amplitude, reduced (20 %) contractile frequencies of antrum and duodenum, and improved antroduodenal coordination (25 → 60 %). The minimal effective dose was 0.31 mg/kg p.o. Cisapride was significantly more effective than metoclopramide on all parameters tested. Isopropamide (0.04 mg/kg i.v.) abolished the motor-stimulating effects of cisapride. Cisapride accelerated the emptying of a liquid (gastric cannula dogs) and semi-solid and solid (Tc-99m tin colloid labelled) test meal. Minimal effective dose was 0.16 mg/kg i.v. In the interdigestive state, cisapride (0.63 mg/kg i.v.) induced contractions on antrum and duodenum as strong as but not similar to phase III contractions. Cisapride appears to be a potent stimulator of digestive and interdigestive gastroduodenal motility. It improves gastric emptying of liquid, semi-solid and solid test meals.