Abstract
It was shown that a single intraperitoneal injection of extract (fraction 3 and 4) from roots of Panax ginseng C. A. MEYER, increased activity of RNA polymerase (EC 2.7.7.6), assayed in vitro, of deoxycholate-lysed nuclei of rat liver. The maximum increase of the enzyme activity was found at 2 hr with a lag period of 30 min after treatment. The increase was still observed 8 hr after the injection of the extract but disappeared after 16 hr. The increase in the activity was found in the presence of high concentration of ammonium sulfate in vitro as well as in the absence of the salt.Three hours after treatment in vivo, a little increase of protein synthesis was also observed in liver homogenate or nuclei and abolished by prior administration of puromycin. The increase in the activity of the polymerase due to ginseng extract did not disappear even when the synthesis of bulk nuclear protein was greatly inhibited by puromycin.
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