Stichopus hermanii stimulation to Runx2 expression as Periodontal Remodeling Biomarkers to accelerate Orthodontic Tooth Movement

Abstract

The aim of this study is to investigate S.hermanii stimulation to Runx2 expression in periodontal remodeling during orthodontic tooth movement. In the experimental method twenty four males Cavia Cobaya were divided into three groups. K(-) group as negative control, a group (without treatment), K(+) group as positive control, a group which were applied separator rubber and helical spring for orthodontic tooth movement, and P groups were applied with orthodontic force and treated with S.hermanii 3.5%. After treating the C. cobaya were sacrificed. Runx2 expression as a periodontal remodeling were examined with immunohistochemistry. The results showed that orthodontic tooth movement means and SD in K(-), K(+), P are 2.99±0.065; 4.38±0.035; 5.05±0.199; while the mean and SD of Runx2 expression is : 5.25±1.031; 2.38±0.46; 12.13±0.875. Kruskal Wallis and Mann Whitney test exhibited orthodontic tooth movement and Runx2 expression were significantly increased with S.hermanii application (p<0,05). Based on the result we concluded that S.hermanii accelerate orthodontic tooth movement. Increasing Runx2 expression with S.hermanii showed that increasing periodontal remodeling.