Stevens-Johnson Syndrome Induced by Methotrexate, An Uncommon Adverse Drug Reaction: A Case Report

Abstract

Adverse drug reactions (ADRs) can lead to severe consequences and increased mortality rates. This case report focuses on a 41-year-old woman, who developed methotrexate-induced Stevens-Johnson syndrome (SJS), emphasizing the importance of recognizing and managing such a patient. The patient exhibited recurrent vomiting, maculopapular rashes, erosions and ulcers in multiple locations, consistent with SJS. These symptoms highlight the severity of the adverse drug reaction. Treatment involved was the discontinuation of medications, oral ointments, gargles, prophylactic antibiotics, and blood transfusion. Significant improvement was observed after 15 days of treatment. This case report underscores the life-threatening nature of methotrexate-induced SJS. Early recognition, discontinuation of offending medications, and prompt intervention are crucial to mitigate harm. Raising awareness about ADRs and their management is vital for enhancing patient safety and outcomes.