STEVENS-JOHNSON SYNDROME IN SINONASAL UNDIFFERENTIATED CARCINOMA PATIENT DUE TO CHEMOTHERAPY

Abstract

A 40-year-old woman diagnosed with sinonasal undifferentiated carcinoma was referred by the nursing team due to a "fetid odor that diffuses throughout the environment." In her medical history, the patient had multiple episodes of hypersensitivity reactions due to penicillin, cisplatin, and fluorouracil. On physical examination, an extensive area of gingival necrosis, presenting as a large and painful ulcerated area with exposure of the buccal and lingual mandibular bone, resulting in dental root exposure, was noticed. Skin ulceration and pigment change in both hands and arms were present. In a multidisciplinary approach, chemotherapy was interrupted and an intravenous antibiotic was administered. For oral lesions, chlorhexidine 0.12% and nystatin mouthwash were prescribed 4 times a day. In addition, weekly antimicrobial photodynamic therapy was performed. After 4 weeks of clinical follow-up, oral lesions were healing, and areas of epithelialization were seen. Unfortunately, the patient died from her malignancies during follow-up.