Abstract
Introduction. Ribociclib is a cyclin-dependent kinase (CDK) inhibitor, widely used in patients with different types of cancer. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe immunologic skin reactions that lead to epidermal necrolysis followed by exfoliation with life-threatening consequences. Case presentation. We present a case of a patient with metastatic breast cancer with SJS-like skin reaction during treatment with ribociclib and letrozole. The patient presented skin changes, typical clinical symptoms (with Nikolsky sign), and destruction of the epithelium by forming blisters and abscesses on pathological examination. The lesions covered about 30% of the skin surface, and they were scored as grade 4 according to CTCAE v. 5.0. After ribociclib discontinuation and supportive management, a gradual improvement of skin lesions was observed. Conclusion. We present this case as there are only a few case reports on ribociclib-related Stevens-Johnson syndrome in the literature, and clinicians should be aware of the risk of this side effect.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
