Steroid-sensitive nephrotic syndrome in children.

Abstract

A group of experts from the International Pediatric Nephrology Association (IPNA) has recently updated recommendations for steroid-resistant and steroid-sensitive nephrotic syndrome (SRNS and SSNS) in children [1, 2]. SSNS is now defined as idiopathic nephrotic syndrome [spot urinary protein:creatinine ratio (UPCR) ≥200 mg/mmol and albuminemia <30 g/l] responsive to 4 weeks of corticosteroid therapy with or without a confirmation period of 2 additional weeks (late SSNS). We present a summary of the new definitions and recommendations for diagnosis and management of SSNS in children (Fig. 1). ... ... ... ... ... There is no randomized controlled trial comparing a 4 + 4 to a 6 + 6-week course of treatment for the initial episode of SSNS. Therefore, both are recommended in line with Kidney Disease: Improving Global Outcomes guidelines [2, 4, 5].