Abstract
Seven steroidal saponins were isolated from the stems of Nolina recurvata, five of which appeared to be new compounds and were assigned as spirosta-5,25(27)-diene-1β,3β-diol (neoruscogenin) 1-O-{O-α- l-rhamnopyranosyl -(1 → 2)-O-[β- d-xylopyranosyl -(1 → 3)]-α- l-arabinopyranoside }, (25 S)- spirost-5-ene-1 β,3 β-diol [(25 S)-ruscogenin] 1-O-{O-α- l-rhamnopyranosyl -(1 → 2)-O-[β- d-xylopyranosyl -(1 → 3)]-α- l- arabinopyranoside }, neoruscogenin 1-O-{O-α- l-rhamnopyranosyl -(1 → 2)-O-[β- d-xylopyranosyl-(1 → 3)]-β- d-fucopyranoside }, 26-O-β- d-glucopyranosyl -22-O- methylfurosta-5,25(27)-diene-1β,3β,22ξ,26- tetrol 1-O-{O-α- l-rhamnopyranosyl - (1 → 2)-O-[β- d-xylopyranosyl -(1 → 3)]-α- l-arabinopyranoside } and 26-O-β- d-glucopyranosylfurosta - 5,20(22),25(27) - triene - 1β,3β,26 - triol 1 - O - {O - α - l - rhamnopyranosyl - (1 → 2) - α - l - arabinopyranoside }. The isolated saponins were evaluated for their inhibitory activity on cyclic AMP phosphodiesterase to identify new compounds with medicinal potential.
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