Abstract
1524 Background: Breast cancer is the 2nd cause of women mortality in Mexico, increasing this rate over the past ten years. Functional polymorphisms in genes encoding steroid metabolizing enzymes may contribute to this understanding by serving as surrogate markers for altered long-term hormone exposure and, thus, as biomarkers of individual breast cancer susceptibility. In order to determine the impact of CYP17 and CYP1A1 genotypes on the risk to develop breast cancer, we realized a case-control study of breast cancer patients and healthy controls among women invited to participate in this study from a Public Hospital in Mexico City. Methods: 90 breast cancer patients and 87 healthy controls, who had given their informed consent were included. All breast cancer patiens had pathologically confirmed as breast carcinoma, all were diagnosed and treated at the “1o de Octubre” hospital. Epidemiological questionnaire and genotyping data were obtained. CYP17 and CYP1A1 were genotyped using PCR/restriction fragment lenght polymorphism. For CYP17 a single nucleotide polymorphism at the 5‘untraslated region of the CYP 17 was done (MspA1 restriction sitie). Two polymorphism for CYP1A1 were analized: 2455 A>G (CYP1A1*2B) and 4889 A >G (CYP1A1 *2C). Results: We found an increased risk of breast cancer in women carrying the allele CYP1A1*2B. The odds ratio was 2.6 (CI95%= 1.08–6.4; p <0.032). In the stratified analysis, this risk was increased when CYP1A1*2B and CYP1A1*2C were presented together. The odds ratio was 3.4 (CI95%= 1.2- 9.3; p<0.017). Regarding the CYP17 genotype, it was not preliminary associated with breast cancer risk. Conclusions: These results suggest that CYP1A1*2B and CYP1A1*2C genotype could be a biomarker for breast cancer risk in our general Mexican population. It‘s necesary to increase the sample size and add others genes encoding steroid metabolizing enzymes. No significant financial relationships to disclose.
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