Abstract
In recent years, strains of different Clostridia species capable of metabolising steroids have been isolated from human faecal flora and from sewage. The organisms (enzymes) are C. cadaveris (20β-reductase and C17-20 desmolase); C. sporogenes (C21-hydroxy-acetylase); C. paraputrificum (3α-hydroxy-5β-reductase, chemically known as hydroxy steroid dehydrogenase, HSDH) and C. innocuum (3β,5β-HSDH). Examination of type and stock culture strains from different sources demonstrated that synthesis of steroid metabolising enzymes was characteristic for the species. Of sixteen type/neotype strains not previously reported to synthesise steroid active enzymes, fourteen produced a C21 hydroxy acetylase, and two, C. glycolicum and C. carnis , a 3α, 5β-HSDH. Keywords: Clostridia; Enzymatic markers; Species specificity; Steroid metabolising enzymes.
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