Abstract
s1 May 1969Steroid Inhibition of Adrenal Corticosteroid Production—A Mitochondrial Effect.Gerard N. Burrow, M.D., F.A.C.P.Gerard N. Burrow, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1060_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is evidence to suggest that certain steroids are capable of inhibiting corticoid production as well as protein and ribonucleic acid (RNA) synthesis in rat adrenal glands in vitro. The data suggest the possibility of local feedback inhibition of steroidogenesis by adrenal steroids, but the mechanism of the inhibition is not clear. The finding that the addition of adenine triphosphate (ATP) and an ATP-generating system overcame corticosterone inhibition of14C-leucine incorporation into rat adrenal protein in vitro suggested an inhibitory effect on cellular energy processes. To study this further, rat adrenal mitochondria were prepared by differential centrifugation, and the effect... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1060-1061KeywordsAdenineAdenosine triphosphateAdrenal glandsMitochondriaProtein synthesisProteinsRNASteroidogenesis Issue Published: 1 May 1969 PDF downloadLoading ...
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