Abstract
When many of us think of steroid hormones and their receptors, our mind leaps to the nucleus, with images of receptors binding to DNA and regulating gene transcription. In recent years, an onslaught of investigations has forced new, but still fuzzy, images into our brains of steroid hormone action outside of the nucleus. Although decades ago it was noticed that steroids have important non-genomic physiological consequences, and the anti-atherosclerotic affect of estrogen is particularly important for post-menopausal women receiving hormone-replacement therapy, it has only been in the past few years that the cytoplasmic pass-times of steroid hormone receptors have been subject to intensive molecular investigation.
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