Abstract
Summary Steroid hormone levels were measured in the blood and urine of 69 patients with carcinoma of the lung with the following findings: 1. Men with epidermoid carcinoma excrete abnormally large amounts of 17-hydroxycorticosteroid in the urine. 2. They also have normal 8:00 a.m . plasma cortisol levels, but 4:00 p.m . and 10:00 p.m . levels are elevated which indicates a loss of normal corticosteroid circadian rhythm. 3. ACTH testing suggests adrenal hyper-responsiveness in men with epidermoid carcinoma. 4. Men with epidermoid carcinoma excrete excess quantities of total urinary estrogen, the majority of which is accounted for by an excess excretion of estriol. 5. Significant abnormalities were not found in other carcinoma cell types in men or in any of the carcinomas in women. The sample size in each instance, however, was small. The current data are discussed in relation to that previously reported in the literature.
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