Abstract
A detailed study has been made of the urinary excretion of steroid hormones and their metabolities in an adrenalectomized woman during 3 successive pregnancies. The excretion values for urinary estrogens, pregnanediol, pregnanetriol, and testosterone were abnormally low. The levels for dehydroepiandrosterone (DHA) were also low, being generally undetectable by the assay methods used. Cortisol production rates (CPR) estimated in the mother during the third trimester of pregnancy were in the range normally encountered in the newborn infant. The data reported herein are in keeping with the view that the maternal adrenal is an important source of steroid precursors during pregnancy.
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