Abstract
1. 1. Two synthetic steroids, 17-acetoxy-6α-trifluoromethylpregn-4-ene-3, 20 dione and 17-acetoxy-3β(β-carboxypropionyloxy)-6-trifluoromethyl-pregn-5-ene-20-one, were found to cause liver enlargement in rats and hypertrophy of the smooth endoplasmic reticulum. 2. 2. Evidence is now presented that the same two compounds cause a widening of the substrate specificity of a particular “fast esterase” zone. This is detected by starch electrophoresis of liver homogenate from adult treated rats. It is also shown that this wider specificity is normal in the young liver. 3. 3. The results are discussed from the point of view of hormones as inducers of enzymes and as regulators of gene action.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
