Abstract

Background/ObjectivesSternal-wound infections (SWIs) are rare but consequential healthcare-healthcare-associated infections following coronary artery bypass graft surgery (CABG). The impact of SWIs associated on the cost of health care provision is unknown. The aim of this study was to quantify the burden of CABG-related SWIs across countries with mature health care systems and estimate value-based purchasing (VBP) levels based on the local burden.MethodsA structured literature review identified relevant data for 14 countries (the Netherlands, France, Germany, Austria, the United Kingdom, Canada, Italy, Japan, Spain, the United States, Brazil, Israel, Taiwan, and Thailand). Data, including SWI rates, CABG volume, and length of stay, were used to populate a previously published Markov model that simulates the patient’s CABG-care pathway and estimates the economic (US$) and care burden of SWIs for each country. Based on this burden, scenarios for VBP were explored for each country. A feasible cost of intervention per patient for an intervention providing a 20% reduction in the SWI rate was calculated.ResultsThe SWI burden varied considerably between settings, with SWIs occurring in 2.8% (the United Kingdom) to 10.4% (the Netherlands) of CABG procedures, while the costs per SWI varied between US$8172 (Brazil) to US$54 180 (Japan). Additional length of stay after SWI was the largest cost driver. The overall highest annual burden was identified in the United States (US$336 million) at a mean cost of US$36 769 per SWI. Given the SWI burden, the median cost of intervention per patient that a hospital could afford ranged from US$20 (US$13 to US$42) in France to US$111 (US$65 to US$183) in Japan.ConclusionsSWIs represent a large burden with a median cost of US$13 995 per case and US$900 per CABG procedure. By tackling SWIs, there is potential to simultaneously reduce the burden on health care systems and improve outcomes for patients. Mutually beneficial VBP agreements might be one method to promote uptake of novel methods of SWI prevention.

Highlights

  • Healthcare-associated infections (HAIs), which are infections contracted in hospital while in care for another condition, represent a significant clinical and economic burden to hospitals and their patients.[1]

  • sternal-wound infection (SWI) represent a large burden with a median cost of US$13 995 per case and US$900 per coronary artery bypass graft surgery (CABG) procedure

  • Required data were identified for France, Germany, the Netherlands, the United Kingdom and the United States (Figure 1)

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Summary

Introduction

Healthcare-associated infections (HAIs), which are infections contracted in hospital while in care for another condition, represent a significant clinical and economic burden to hospitals and their patients.[1]. In the United States, the annual economic burden of HAIs has been estimated to range between US$28 billion and US$45 billion, with HAIs affecting 2 million patients and causing 90 000 deaths yearly.[3] Costs vary from prolonged impatient. View this license’s legal deed at http://creativecommons.org/licenses/by/4.0 and legal code at http://creativecommons.org/licenses/by/4.0/legalcode for more information

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