Sterilization of Media for Biochemical Processes

Abstract

Publisher Summary This chapter presents biochemical processes for sterilizing media. Recent developments have resulted in the use of ionizing radiations for bone sterilization in surgery, for specialized pharmaceutical applications, and, potentially for many other situations. Continuous, high-temperature heat sterilization has been successfully adapted to fermentations from previous use in food processing. The contradiction between Z value and activation energy calculations has not been resolved; in fact, it has not even been adequately recognized. Improved flash processing schedules should be possible when data become available from spore destruction studies at higher temperatures. Studies should justify one or the other of the calculation methods, provided either is valid at high temperatures. Radiation sterilization may become useful in the beverage alcohol and in some other fermentation. However, its adaptation to industrial use is contingent upon development of better and cheaper irradiating equipment.