Abstract
A structure selectivity relationship was established by systematically increasing the steric of the ligands from phenyl substituent to mesityl on the pyridine ring of Pyox and isopropyl to tert-butyl group on the oxazoline ring. The ligand 6MesPyoxsBu bearing a sterically demanding mesityl group at position 6 of the pyridine ring showed optimum catalytic activity for Heck-Matsuda desymmetrization reaction of non-activated cyclopentene using Pd(tfa)2 as the catalyst. A wide range of arenediazonium salts bearing electronically distinct substituents was evaluated in Heck-Matsuda coupling, which resulted in good to excellent isolated yields (67–92 %), excellent enantio- and diastereoselectivity (up to 96 % ee, >20:1 dr).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
