Abstract
BackgroundOur aim is to report treatment efficacy and toxicity of patients treated by robotic (Cyberknife®) stereotactic body radiotherapy (SBRT) for oligorecurrent lung metastases (ORLM). Additionally we wanted to evaluate influence of tumor, patient and treatment related parameters on local control (LC), lung and distant progression free- (lung PFS/Di-PFS) and overall survival (OS).MethodsConsecutive patients with up to 5 ORLM (confirmed by FDG PET/CT) were included in this study. Intended dose was 60Gy in 3 fractions (prescribed to the 80% isodose volume). Patients were followed at regular intervals and tumor control and toxicity was prospectively scored. Tumor, patient and treatment data were analysed using competing risk- and Cox regression.ResultsBetween May 2010 and March 2016, 104 patients with 132 lesions were irradiated from primary lung carcinoma (47%), gastro-intestinal (34%) and mixed primary histologies (19%). The mean tumor volume was 7.9 cc. After a median follow up of 22 months, the 1, 2 and 3 year LC rate (per lesion) was 89.3, 80.0 and 77.8% respectively. The corresponding (per patient) 1, 2 and 3 years lung PFS were 66.3, 50.0, 42.6%, Di-PFS were 80.5, 64.4, 60.6% and OS rates were 92.2, 80.9 and 72.0% respectively. On univariable analysis, gastro-intestinal (GI) as primary tumor site showed a significant superior local control versus the other primary tumor sites. For OS, significant variables were primary histology and primary tumor site with a superior OS for patients with metastases of primary GI origin. LC was significantly affected by the tumor volume, physical and biologically effective dose coverage. Significant variables in multivariable analysis were BED prescription dose for LC and GI as primary site for OS. The vast majority of patients developed no toxicity or grade 1 acute and late toxicity. Acute and late grade 3 radiation pneumonitis (RP) was observed in 1 and 2 patients respectively. One patient with a centrally located lesion developed grade 4 RP and died due to possible RT-induced pulmonary hemorrhage.ConclusionsSBRT is a highly effective local therapy for oligorecurrent lung metastases and could achieve long term survival in patients with favourable prognostic features.
Highlights
Our aim is to report treatment efficacy and toxicity of patients treated by robotic (Cyberknife®) stereotactic body radiotherapy (SBRT) for oligorecurrent lung metastases (ORLM)
All patients were referred for SBRT after full staging including baseline registration of the pulmonary function, chest and abdominal diagnostic computed tomography (CT) and [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT imaging confirming local control at the primary tumor site and the absence of non-pulmonary metastases
In case of a second de-novo metachronous-or repeat ORLM, a new SBRT session was the treatment of choice in 42 patients
Summary
Our aim is to report treatment efficacy and toxicity of patients treated by robotic (Cyberknife®) stereotactic body radiotherapy (SBRT) for oligorecurrent lung metastases (ORLM). SBRT for OMLD yields high local control and low toxicity rates; in case of limited (maximal 5) lung metastases, the 2-year local control varies between 78 and 96% [6,7,8,9,10]. The term OMLD has been further refined with the concept of oligorecurrent lung metastases (ORLM), defined as the development of metachronous lung oligometastases after radical treatment of the primary tumor [11]. This refinement rules out patients presenting with OMLD at initial diagnosis or OMLD with an uncontrolled primary tumor. Several studies suggest an improved outcome for patients with ORLM when compared to synchronous OMLD [12, 13]
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