Abstract
背景与目的随着放疗技术的快速发展,立体定向放射治疗(stereotactic body radiation therapy, SBRT)已得到广泛应用,且在早期非小细胞肺癌(non-small cell lung cancer, NSCLC)治疗中取得与手术相当的疗效。非均整模式移除了加速器的射野均整器,其剂量率远高于常规均整模式,缩短治疗时间,但目前临床应用较少。本研究旨在探讨非均整模式SBRT治疗的安全性和有效性。方法选取2011年12月-2013年12月期间的T1-2N0M0原发NSCLC,术后肺内孤立复发转移,以及Ⅳ期肺内寡转移灶者共31例,予以内在大体肿瘤靶区60 Gy/8 f或48 Gy/4 f的非均整模式SBRT治疗。结果非均整模式比常规均整模式明显缩短了治疗时间,靶区剂量相当,且未增加正常组织受量。患者中位随访时间为19.4个月。1年的局部控制、区域控制、远处转移控制、无疾病进展和总生存率分别为96.8%、96.8%、83.9%、77.4%和96.8%。最常见的副反应为放射性肺炎(1级29%,2级3.2%)和胸痛(1级12.9%,2级6.5%),发生率较低。结论相比既往常规均整模式,使用非均整模式大分割放射治疗技术治疗肺部小肿瘤是安全、有效的,但长期效果仍需进一步随访、研究。
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