Abstract
The glutamate (Glu) analog, dl-alpha-aminoadipate ( dl-αAA), and the separate d and l isomers of αAA, were administered subcutaneously to infant mice and histopathological effects on the arcuate hypothalamic (AH) nucleus were studied. l-αAA induced striking gliotoxic and neurotoxic changes; d-αAA and dl-αAA respectively induced mild and extreme gliotoxic but not neurotoxic changes. The neurotoxicity of l-αAA is of interest in view of its known neuroexcitatory potential. The non-neurotoxicity of dl-αAA implies effective antagonism by d-αAA of the neurotoxicity of l-αAA, which is of interest in that d-αAA is recognized as an effective antagonist of amino acid excitants and is thought to block specifically at the excitatory receptor.
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