Abstract
We have previously reported that the intraventricular injection of acetylcholine increases latency in the mouse tail-flick test, the ED50 being 7.3 ug (1). This effect was reversed by five narcotic-antagonist analgesics in the same order of potency in which they antagonized morphine, and was found to be due to muscarinic receptor stimulation. It was also pointed out at that time that the intraventricular injection of acetylcholine would block the writhing response to intraperitoneally administered p-phenyl-quinone. In this preliminary communication, we present our results of the effect of the intraventricular injection of acetyl-choline on writhing induced by intraperitoneally administered acetylcholine. In addition, we present results of our studies in which we demonstrated stereospecificity of intravetricularly administered ministered acetylmethylcholines in causing antinociception.
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