Abstract
4,5-Dicyanoimidazole has been reacted with racemic and enantiopure alcohols 1 under Mitsunobu conditions to give 1-alkyl-4,5-dicyanoimidazole derivatives 2, which in turn have been transformed by hydrolysis and decarboxylation into 1-alkylimidazoles 4 in good overall yield and high enantiomeric excess. The absolute stereochemistry of the compounds has been confirmed by synthesizing 4c through an independent route.
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