Abstract
Abstract The chronic infusion of amphetamine or a single injection of the drug to iprindole-treated rats produces long-term, possibly neurotoxic, effects on strialal dopamine (DA) neurons. Significant decreases in striatal DA. dihydroxphenylacetic acid (DOPAC), and homovanillic acid (HVA) were observed one week after the administration of 6.9 and 9.2 mg/kg of S(+)- but not after doses of R(−)-amphetamine sulfate up to 46 mg/kg to iprindole-treated rats. Concentrations and half-lives of the isomers in the brains of iprindole-treated rats were not different.
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