Stereospecific ligands and their complexes IX: Synthesis, characterization and antimicrobial activity of ethyl esters of ( S, S)-ethylenediamine- N, N′-di-2-propanoic and ( S, S)-ethylenediamine- N, N′-di-2-(3-methyl)-butanoic acids and corresponding platinum(IV) complexes: Crystal structure of tetrachloride-( O, O′-diethyl-( S, S)-ethylenediamine- N, N′-di-2-propanoato)-platinum(IV), [PtCl 4(det- S, S-eddp)

Abstract

The synthesis of ethyl esters of ( S, S)-ethylenediamine- N, N′-di-2-propanoic and ( S, S)-ethylenediamine- N, N′-di-2-(3-methyl)-butanoic acids and corresponding platinum(IV) complexes are reported. The complexes have been prepared by direct reaction of K 2[PtCl 6] and ethyl esters of the acids mentioned above. The esters and complexes were characterized by elemental microanalysis, infrared, 1H and 13C NMR spectroscopy. The spectroscopically predicted structures of the synthesized complexes were confirmed by X-ray analysis of the [PtCl 4(det-( S, S)-eddp)]. Antimicrobial activity of ligands and corresponding platinum(IV) complexes was investigated against 29 species of microorganisms. Testing was performed by microdilution method and minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) have been determined. Tested ligands and corresponding platinum(IV) complexes demonstrated the significant activity against some G+ bacteria. On the other hand, these complexes demonstrated moderate and low antibacterial and antifungal activity.