Abstract
The syntheses of two novel platinum(IV) complexes of formula [PtX 2( S, S-eddp)]· nH 2O ( S, S-eddp = ethylenediamine- N, N′-di- S, S-2-propanoate ion, X = chlorido ( 1) or bromido ( 2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine- N, N′-di- S, S-2-propanoic acid (H 2- S, S-eddp). The complexes were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt( S, S-eddp)Cl 2]·4H 2O and uns-cis-[Pt( S, S-eddp)Br 2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin.
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