Stereoselective total synthesis of polyether ionophore antibiotics, isolasalocid A and lasalocid A. part 2. the total synthesis via stereoselective construction of the B rings by chelation-controlled cyclization under thermodynamic conditions.

Abstract

Stereoselective total synthesis of isolasalocid A ( 1) and lasalocid A ( 2) was achieved via construction of the tetrahydrofuran rings by chelation-controlled cyclization of the corresponding p-methoxyphenyl substituted allyl alcohols ( 6, 7) under thermodynamic conditions.