Stereoselective total synthesis of achaetolide and reconfirmation of its absolute configuration

Abstract

The stereoselective total synthesis of achaetolide 1 has been achieved and its absolute stereochemistry has been reconfirmed to be 3 S,6 R,7 S,9 R configuration. Keck allylation, Sharpless asymmetric dihydroxylation, and ring closing metathesis are the key steps involved in the target synthesis.