Abstract
A facile stereoselective approach for the total syntheses of (R)-strongylodiols A, B, C and D is described. A chiron approach has been followed wherein the stereochemistry at the chiral center is fixed and a methodology of base induced elimination of β-alkoxy chloride to get the chiral propargyl alcohol is employed. A key intermediate synthesized from commercially available (-)-diethyl D- tartrate has been utilized for the total syntheses of all the four titled compounds.
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