Abstract
We present here the application of Grubbs’ 2nd generation catalyst for the ring-closing metathesis of electron-deficient α,β-unsaturated amides and esters leading to the synthesis of enantiopure azepinone and oxepinone derivatives on a carbohydrate glycoside scaffold. The relative stereochemistries of the compounds obtained were corroborated by X-ray crystallography, 1H NMR or deduced based on previously reported results. These compounds are designed as precursors of new polyhydroxylated heteroannulated sugars with potential biological activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have