Stereoselective synthesis of novel cyclobutane dehydro amino acids from (+)-α-pinene

Abstract

Several title compounds have been synthesized in good overall yields through highly stereoselective Wittig-Horner condensations of suitable phosphonates with enantiopure aldehydes easily obtained from α-pinene as chiral precursor. These products, presenting two asymmetric carbons, two or four prochiral centers, and appropriate chemical functions, are versatile precursors to a variety of cyclobutane amino acid derivatives.