Stereoselective synthesis of higher homologues of pantolactone from (R)-glyceraldehyde acetonide

Abstract

A stereoselective synthetic route has been developed toward the synthesis of novel γ-substituted pantolactone homologues using Sharpless asymmetric dihydroxylation of the enantiomeric alkene–ester intermediates, derived from (R)-glyceraldehyde acetonide, as the key step.