Abstract
The orthogonally protected gylcosylated amino acid building block 1 for the synthesis of peptidomimetics was prepared by the coupling of an amino acid aldehyde with a glycosyl dianion of glucosamine. This new C-glycosylated amino acid displays an improved metabolic stability and thus an improved bioavailability because of the single carbon chain between the sugar residue and the amino acid and because of the CC linkage at the anomeric center.
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