Abstract
The straightforward and completely (Z)-stereoselective synthesis of various 3-substituted ethyl 4,4,4-trifluoro-2-formyl-amino-2-butenoates, useful dehydro amino acid precursors of β-trifluoromethyl substituted amino acids, is described. Key step is the Schollkopf formylamino-methylenation protocol starting from ethyl isocyanoacetate and trifluoromethyl ketones.
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