Abstract
An efficient synthesis of novel 3′-substituted 2′,3′-dideoxynucleoside analogues in the pyrazolotriazine series was developed from the corresponding 3′-ketonucleoside via the Wittig reaction. On the other hand, a highly stereoselective addition of alkynylcerium reagents to the same precursor led to the 3′-alkynyl-2′-deoxynucleosides in one step with the natural stereochemistry. Applications to produce novel P2Y 1 receptor antagonists or new anti-retroviral nucleoside analogues are suggested.
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