Abstract
The olivomycins are representative antitumor antibiotics in the aureolic family of the compounds, which contains the tricyclic aglycon core, olivin. In this study, we established the efficient synthesis of the anthracenone core skeleton based on a cycloaddition reaction between the homophthalic anhydride and the chiral cyclohexenone derivatives, which is promoted by the combined use of molecular sieves, proton sponge, and a Lewis acid. The cyclohexenone with four chiral centers was synthesized by asymmetric and diastereoselective reactions, and was subjected to the cycloaddition reaction with a homophthalic anhydride followed by a sequence of reactions to accomplish stereoselective synthesis of (+)-2-deoxyolivin.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
