Abstract
The stereoselective synthesis of 22-oxacalcitriol (OCT) has been achieved. The triene system was introduced using the Lythgoe–Hoffmann La Roche convergent Wittig–Horner approach to couple ketoester 7 with A ring phosphine oxide 8 . The value of the resulting ester 6 for synthesis of C25-modified OCT analogues is exemplified by the synthesis of 5 .
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