Stereoselective Synthesis of 2‐Deoxy‐α‐N‐Glycosides from Glycals with 1,4,2‐Dioxazol‐5‐ones

Abstract

Comprehensive SummaryThe synthesis of N‐glycosides has received significant attention due to their crucial role in carbohydrate chemistry. Despite considerable advancements developed in the construction of N‐glycosides, methods for the stereoselective construction of 2‐deoxy‐α‐N‐glycosides are still limited. Herein, we disclosed a nickel‐catalyzed hydroamination of glycals under mild conditions. This transformation could allow for the stereoselective synthesis of an array of 2‐deoxy‐α‐N‐glycosides with excellent α‐stereoselectivity. Nickel‐catalyzed glycosylation reactions, particularly those involving anomeric C(sp3)‐metal bond formation, have proven to be an effective and stereoselective strategy for producing various N‐glycosides. Additionally, with highlight of the application of this reaction, γ‐sugar amino acid derivatives were synthesized.