Abstract
Highly selective reductions of 5-acyl-2-isoxazolines and conversion of the resulting syn-5-hydroxyalkyl-2-isoxazolines into syn-diols are key steps in concise syntheses of (±)-exo-brevicomin, and (±)-pestalotin. With an asymmetric nitrile oxide as starting material, cycloaddition with the acrylate derivative of Oppolzer's camphor sultam leads to a synthesis of (–)-pestalotin.
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