Abstract
Abstract A systematic study of the diastereoselective addition of methyl organometallic compounds to the benzyl imine derived from conveniently protected D -glyceraldehyde in order to develop a new approach to enantiomerically pure α-hydroxy-β-amino acids is reported. Methylmagnesium bromide addition afforded the corresponding adduct, which can be further elaborated to give (2 S ,3 R )-3- amino -2- hydroxybutanoic acid, with complete diastereoselectivity.
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